Quantitative evaluation of the antiretroviral efficacy of dolutegravir
نویسندگان
چکیده
منابع مشابه
Quantitative evaluation of the antiretroviral efficacy of dolutegravir.
The second-generation HIV-1 integrase strand transfer inhibitor (InSTI) dolutegravir (DTG) has had a major impact on the treatment of HIV-1 infection. Here we describe important but previously undetermined pharmacodynamic parameters for DTG. We show that the dose-response curve slope, which indicates cooperativity and is a major determinant of antiviral activity, is higher for DTG than for firs...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2016
ISSN: 2379-3708
DOI: 10.1172/jci.insight.90033